COLLAGEN VITAL POWER is a unique and powerful functional dietary supplement.

Our expertise is to combine formulation, dosage, concentration and bio-availability in an innovative supplement that will be active within your body to boost and regenerate from inside the depleted collagen.

All scientists agree on correlation between dosage and efficacy. This is why COLLAGEN VITAL POWER has been customized with 10 g highly bio-available collagen peptides.

Highlights of several key scientific studies proving benefits of collagen peptides intake, including several made with COLLAGEN VITAL POWER raw material, are presented below as a reference for deeper investigation into the role of collagen peptides supplementation to counteract signs of aging, whether with skin beauty or joint and bone health.

AGE INDUCED COLLAGEN LOSS(1)

Women aged 20-60 years have been tested for bone mineral density and collagen content in skin biopsies from lower abdomen. This study enabled to show relationship between age and collagen loss.

The results indicate that skin collagen levels decreased significantly with age after the age of 40 and after the menopause.

collagen age loss

SKIN BEAUTY(2,3)

skin without collagen skin results 2

  1. Skin without collagen supplementation

  2. Skin after 3 months collagen supplementation, 10g

Greater surface occupied by collagen network and less voids (white marks) in picture (b) 

1) Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides used by Collagen Vital Power (CVP) on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo.

The results of this study demonstrated that after 12 weeks of intake, there was a 31% reduction, compared to the start of the study. This restructuring of the skin is key to our understanding of how Collagen Vital Power can boost the collagen network, providing clear anti-aging benefits.

placebo vs Collagen Vital Power

skin hydration

2) A double-blind, placebo-controlled trial of collagen peptides used by Collagen Vital Power among women aged 40-59 has demonstrated that this supplementation with collagen peptides has increased skin hydration by 28% after eight weeks; and 91% of this research group reported a higher skin hydration level during the same period.

JOINT HEALTH(4)

1)Double-blind placebo-controlled clinical study revealed that an 8 g daily intake of collagen peptides used by Collagen Vital Power significantly improved joint comfort and functionality. During the 6-month study, women with diagnosed knee osteoarthritis were randomly assigned either 8 g of this collagen or a placebo. Their knee joint function was assessed with standardized score systems (WOMAC for general joint discomfort and function and Lysholm for more specific functions when walking, jumping and stair climbing).

A new 6-month randomized, double-blind, placebo- controlled study aimed to assess the efficacy of collagen peptides used in Collagen Vital Power (CVP) on knee joint pain and function with selected groups of women between 40 and 70 who presented themselves with knee joint pain or knee joint discomfort. Osteoarthritis was diagnosed by x-ray and quantified using the Kellgren-Lawrence grading system. Only subjects with measured and real osteoarthritis, who had not used nutraceuticals or analgesics within the last 6 months were included. Patients were randomly assigned to receive 8g of CVP or 8g of Placebo per day for a duration of 6 months. Joint pain and function were assessed before (baseline), 3 months after and 6 months after the start of the treatment. For this assessment, two well-established and widely-utilized scoring systems based on standardized questionnaires were used, the WOMAC score

WOMAC score 

Graph 1 is assessing joint pain and function, and the Lysholm score

Lysholm score  

Graph 2 with an emphasis on function of the knee

2) Benito-Ruiz and colleagues have proven the effects of collagen peptides used in Collagen Vital Power on the gene expression of 2 major constituents of the extracellular matrix of the cartilage: aggrecan and type II collagen. CVP collagen specifically enhanced expression of aggrecan and type II collagen mRNA, and thus the chondrocyte gene expression of the cartilage extra cellular matrix components. In this study, it has a similar effect on joint cells as Ibuprofen, a usual medication against inflammation

3) Other studies have also proven that subjects with the greatest joint deterioration benefited the most from the effects of collagen peptides (Moskowitz (2000). Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2):87-99.)

4) Trč and colleagues could demonstrate that collagen peptides were clinically even more efficient than glucosamine in reducing joint pain and improving joint functionality.

BONE HEALTH(4)

Healthy bone is subject to a continuous cycle of bone matrix breakdown and new bone formation. An imbalance between bone resorption and bone formation results in a reduction of bone mineral density (BMD), leading to an increased risk of fractures.

In a model mimicking the loss of bone mass during the onset of menopause, the study provided evidence that collagen peptides used in Collagen Vital Power (CVP) restored bone mineral density and improved bone microarchitecture and solidity.

bone mineral density

bone strenght

SATIETY AND LEAN MUSCULAR MASS(7)

Collagen peptide (HC) is a well-known source triggering satiety effects with a 30 to 50% higher efficacy compared to casein, soya or whey protein.

collagen-peptide

WEIGHT MANAGEMENT AND CELLULITE(8)

In this double-blind, placebo-controlled clinical study, the efficacy of bioactive collagen peptides (BCP) on the cellulite treatment of normal and overweight women has been studied. Women aged 24-50 years with moderate cellulite were randomized to orally receive BCP daily or a placebo over 6 months. The results of the study demonstrated that a regular ingestion of BCP over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite. Based on the current data, it can be concluded that a long-term therapy with orally administered BCP leads to an improvement of cellulite and has a positive impact on skin health.






Bibliography and Scientific references:

(1): C. Castelo-Branco, et al., “Relationship Between Skin Collagen and Bone Changes During Aging,” Maturitas 18, 199-206 (1994).

(2): The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Asserin J, Lati E, Shioya T, Prawitt J (2015) Journal of Cosmetic Dermatology 14 (4): 291-301

(3): Asserin J, Lati E, Shioya T and Prawitt J, 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14: 291–301. doi: 10.1111/jocd.12174

(4): Jiang JX. et al. (2013). Peptan collagen peptides for treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled study. Agro FOOD Industry Hi Tech, Vol 25(2):19-23

(5): Benito-Ruiz P.,Camacho-Zambrano M.M., Carrillo-Arcentales J.N., Mestanza-Peralta M.A., Vallejo- Flores C.A., Vargas-Lopez S.V., Villacis-Tamayo R.A. and Zurita-Gavilanes L.A. 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International journal of food sciences and nutrition, 12:1-15.

Trč T et al. (2011). Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). International Orthopaedics, 35 (3): 341– 348.

(6): F.Guillerminet, et al., “Hydrolyzed Collagen Improves Bone Metabolism and Biomechanical Parameters in Ovariectomized Mice: An In Vitro and In Vivo Study,” Bone 46(3), 827–834 (2010). / F. Guillerminet, et al., “Hydrolyzed Collagen Improves Bone Status and Prevents Bone Loss in Ovariectomized C3H/HeN Mice,” Osteoporosis International 23, 1909–1919 (2012).

A.G. Andrianarivo, et al., “Growth on Type I Collagen Promotes Expression of Osteoblastic Phenotype in Human Osteosarcoma MG-63 Cells,” Journal of Cellular Physiology 153, 256–265 (1992). / M. Mizuno, et al., “Osteoblast-Related Gene Expression of Bone Marrow Cells During Osteoblastic Differentiation Induced by Type I Collagen,” Journal of Biochemistry 129, 133–138 (2001).

(7): Velst M.A.B et al., 2009, A breakfast with apha-lactalbumin, gelatin or gelatin +TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey or whey-GMP, Clinical Nutrition, 28(2): 147-155dhor

(8): Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. Schunck M and al., J Med Food. 2015 Dec;18(12):1340-8.